Acknowledgements

I would like to thank my supervisors Andrei Zinovyev and Vassili Soumelis for guiding this project and enabling me to interact with their teams and sharing the resources. I would also like to thank the U900 lab and his head Emmanuel Barillot to generously equip me with the professional environment, the place and the tools.

I address my gratitude to the TAC committee members Franck Pagès and Denis Thieffry for helping me organizing the jury and giving constructive comments along with my thesis, for being present, at least remotely despite severe weather conditions or travels.

I would also like to express gratitude towards the jury for taking the time to assess this work.

This is also the place to thank the ITMO Cancer - AVIESAN for funding my Ph.D. scholarship and the Pharmacology Faculty of Paris Descartes and specifically Prof. Chantal Guihenneuc for giving me the opportunity to teach in parallel of my Ph.D. as a part of her pedagogical team. I would also thank a lot Center of Interdisciplinary Research for equipping me with unusual skills through numerous courses and Bettencourt Foundation for financing part of the training and sponsoring travel expenses. Special thanks to FdV coordinators: Sofie Leon, David Manset, Elodie Kaslikowski and Maria Molina Calvita for their availability and dynamism. Also, I would express my gratitude for supporting my application for French nationality to François Taddei, director of the FdV Ph.D. school.

Thanks to all people I worked with in both teams: Arnau, Pauline, Gaelle, Paul, Cristobal, Luca, Laura, Laurence, Loredana, Jonas, Floriane, Maude, Philemon, Lilith, Paula, Mihaly, Louis, Caroline. To my FdV mates: Roberta, Juanma, Miza, Guillermo, Aamir and others. To other Ph.D. students of the unit I got along with: Peter, Jo, Hector and Benoît.

This work would never be possible without help and patience of my family, my partner Arnaud and his family. Especially, I would like to thank Arnaud, who managed to be with me on the daily basis, spent the endless hours correcting my writing and speaking, discussed about the code and good practices, was making me laugh when I was coming home tired, angry or unmotivated, and just for being him adorable self. This thesis is dedicated to his father that will not be able anymore to profit from any breakthrough in cancer research.

I am proud to finish the thesis and face new professional adventures. I learned a lot about myself during this three years. I would like to thank very much everyone whom I crossed on this path. I hope to meet you again one day.